What are we doing?
This trial is organised and sponsored by the University of Edinburgh and NHS Lothian. It will run in NHS centres throughout the UK and we will need around 1,550 women to take part in the trial to be able to see how ACS works in twins.
Women with a twin pregnancy who have a planned birth after 35 weeks of pregnancy will be invited to participate in the trial by a member of the maternity team. Planned birth is defined as induction of labour or caesarean section. Women who are eligible and agree to take part in the trial will be given either ACS or a placebo (a dummy drug). A placebo, or dummy drug, is an inactive substance which seems to be a “real medical treatment”. In this trial, the placebo is a harmless salt solution, which will look identical to the ACS. These will be administered by injection prior to the planned birth.
After birth, information on the woman and babies will be collected and fed back to the trial team to analyse.
Why are we doing it?
We hope to establish if there are any effects of ACS for mothers and babies. We will be looking at rates of maternal infection after birth and any impact on breastfeeding. We will also look at any complications in babies. Information about the health of the woman and babies in the period after birth will be taken from medical records. We will collect information until discharge or 28 days postnatal (whichever is sooner).
We will compare the group that did receive ACS and the group that did not to see if there are differences in the health of the woman and babies and the need for extra healthcare support after birth.
Why we think it is important to do this?
Information we obtain from the trial may help inform on the future healthcare of other twin pregnancies. Taking part will help create much needed evidence on the use of ACS prior to a planned birth of twins, which will help women and babies in future. If we find that the use of ACS improves health in twin babies, it could be used in the NHS straight away.
Would you like to read more?
Our team is committed to making research in pregnancy inclusive. We use terms such as ‘women’, ‘maternity’, ‘breastfeed’ and so on, throughout our website, publications and social media accounts, to refer to those who are pregnant, give birth and/or use their breasts to feed a child. We acknowledge that not all people who are pregnant, give birth, and/or breastfeed a child identify as women. It is important that evidence-based care for maternity, perinatal and postnatal health is inclusive and tailored to an individual’s wishes.